Facilitation of frog neuromuscular transmission by sodium fluoride
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چکیده
منابع مشابه
Postsynaptic block of frog neuromuscular transmission by conotoxin GI.
Conotoxin GI, a peptide neurotoxin contained in the venom of the marine snail Conus geographus, was applied to the cutaneous pectoris muscle of the frog, and the effects on the postsynaptic response to acetylcholine were examined. Conotoxin GI reversibly blocked nerve-evoked muscle contractions at concentrations greater than or equal to 3 to 4 microM. Micromolar concentrations of conotoxin GI s...
متن کاملFacilitation and delayed release at single frog neuromuscular junctions.
Facilitation and delayed spontaneous release were recorded from neuromuscular junctions at 2 temperatures. In some experiments, Sr2+ substituted for Ca2+. We measured the ratio of delayed release to resting spontaneous release (D), and the ratio of the second end-plate potential amplitude to the first (F). An extension of the model of Barton et al. (1983) relating Ca2+ to evoked and spontaneous...
متن کاملEffect of sodium nitroprusside and trimetaphan on neuromuscular transmission in the frog.
In summary, it appears from this and other studies that trimetaphan has the potential for producing neuromuscular blockade when used in large doses or when combined with other muscle relaxants. The mode of action appears to be principally that of non-depolarizing neuromuscular blockade. Sodium nitroprusside, on the other hand, even in doses beyond these accepted clinically, does not affect neur...
متن کاملTheophylline, epinephrine, and neostigmine facilitation of neuromuscular transmission.
Epinephrine can enhance transmission under certain conditions in both the central and peripheral portions of the nervous system.'-6 Increased quantities of acetylcholine are released in response to epinephrine at ganglionic and neuromuscular junctions.4, s At the biochemical level, epinephrine stimulates the formation of adenosine 3',5'-phosphate (cyclic AMP) by preparations of many tissues, an...
متن کاملFacilitation of Transmission at the Frog Neuromuscular Junction at O°C Is Not Maximal at Time Zero
Facilitation of quanta1 release has been thought to be maximal immediately after the first action potential in the presynaptic terminal. However, at the frog neuromuscular junction at 0°C no facilitation was observed in response to direct nerve depolarization when the interval between stimulus pairs was less than 10 msec (Dudel, 1988), while at intervals of 20 msec and beyond, facilitation was ...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1987
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1987.tb11351.x